The yeast, squid and scallop powder are used to form a functional flavored additive for nutrition and taste improvement. The amount of dietary is 0, 1, 3, 5%, and fed for 8 weeks of grouper. The growth, crude protein, crude lipid and highly unsaturated fatty acids, There are no significant difference. Feeding flavored additive 5% to 2-4 weeks before sale, can increase flavor amino acids of fish meat. The amount of dietary is 0, 1, 3, 5%, and fed for 2 months of ell. The results showed body length and body weight that there was no significant difference, but condition factor, viscerosomatic index and hepatosomatic index, the control there was a significant difference between the addition of the 3% group. In terms of meat quality, the anterior and middle muscle hardness of the 5% group was significantly higher than that of the other groups, and the control anterior muscle shear force was significantly higher than the other groups. In the crude drug immunization test, rhubarb, astragalus, and licorice compounds to immunosuppressive functional additives. The superoxide dismutase activity of grouper feeding 1.8% added group was significantly higher than that of the other groups at the second weeks. Feeding 1.8% added group, plasma superoxide dismutase activity was significantly higher at the third weeks, higher than the control group. The phenol oxidase activity of plasma was negatively correlated with the amount added of crude drug.