In this study, we used different conditions on clam farming in eastern region and compared the growth effects of clams. In experiment I, we applied bottom sand of different thicknesses (10 cm to 40 cm), and the results showed that there was no significant difference in growth indicators such as weight and shell length of the clams (weight: 40 cm: 1.884±0.315g; 30 cm: 1.787±0.372g; 20 cm: 1.743±0.383g; 10 cm: 1.787±0.247g); the survival rates were also close (40 cm: 64%; 30 cm: 60%; 20 cm: 58%; 10 cm: 62%). Therefore, we presumed that if the bottom sand thickness is more than 10 cm , it will not affect the growth of clams under appropriate conditions. In experiment II, we applied different farming density (500,000-1,500,000 clams/ha, equivalent to 50- 150 clams/m2 ). In terms of clam growth, the results showed that the weight, shell length, shell width and shell height are better at 50 and 75 clams/m2 , and the survival rates were very similar(50 clams/m2 : 94%, 75 clams/m2 : 91%, 100 clams/m2 : 91.5%, 125 clams/m2 : 97%, 150 clams/m2 : 95%). Condition index(CI) of clam was between 6.0 to 6.6%, also there was no significant different among groups. Overall, low-density aquaculture can achieve better growth results in eastern of Taiwan