This plan contained two parts, the fisrt part was verification of fermentation feed, and the other part was the effect of fermentation feed on clams. Results of verification showed that the use of commercial products such as Bacillus, yeast and EM( Effective Microorganisms) for fermentation, the appropriate amount of molasses added was 5%-10%, depending on the C/N ratio of the material. When the addition amount exceeds 15%, it will affect the progress of fermentation and make it slower. The amount of substrate used was 30%. The amount of substrate will affect the speed of fermentation. The more substrate used, the longer it takes to stabilize. The fermentation time of Bacillus completed in less time , and it reached the stable state within 3 days. At the same time, Crude protein of the supernatant in Bacillus group was also higher. After two weeks, there was no vibrio between three groups, indicating probiotics can control the number of Vibrio. The second part was to mix animal and plant proteins (100% fish meal; 75% fish meal and 25% soybean meal, and so on) for fermentation. The results showed that the amount of fermentation feed needs to be controlled, or ammonia and nitrate in the water will increase rapidly. There was no significant difference between the pH of the fermentation feed group and the control group. After 16 weeks, the value of ORP among the groups was similar, while the number of vibrio was higher in the control group. Regarding the growth of clams, the results showed that the fermentation feed produced by mixing fish meal and soybean meal at a ratio of 1:1 could get better growth effects, and condition factors were no significant difference among groups. These results showed that the use of 30% substrate, 10% molasses and Bacillus for fermentation, and the use of 50% soy meal instead of fish meal to make feed can effectively enhance the growth of clams and decrease the number of vibrio.