The addition of 250 μg/mL of Sargassum horneri, Sargassum ilicifolium and Sargassum hemiphyllum var. chinense extract to mouse skeletal muscle cells C2C12 can increase the number of cells to 1.42 times. , 1.74 times and 1.77 times. The degree of phosphorylation of muscle growth factor 4EBP1 was 1.12 times, 1.22 times and 1.20 times of the control group, respectively. The phosphorylation degree of S6K1 was 0.98 times, 1.19 times and 1.18 times of the control group, and the extract was effective to stimulate muscles. Western blot analysis was performed on the upstream regulation factor Rag A/B of this muscle growth pathway, and the protein expression was quantified. It showed that the addition of brown algae extract increased by about 70% compared with the control group, confirming that the brown algae product can open muscle growth. Path to increase muscle performance. In addition, Dexamethasone, a commonly used drug for chronic diseases, induces muscle cell atrophy. The muscle degrading factors Cathepsin-L, myostatin, MuRF1 in C2C12 of skeletal muscle cells were tested. It was found that the various Sargassum products improved at least one index, indicating that it can also be reduced. The side effects of drugs to achieve the purpose of muscle protection.