Use the high C/N ratio to build the biofloc system is a mature technology. In this study, we want to realize the effect of epidemic prevention by using biofloc technolohy for mediate nursery of white shrimp with zero water or a small amount of water exchange. Shrimp larval (PL10) were reared in a biofloc system for 35 days. In the different density of 1500, 3000, 4500, and 6000 ind./ton, their average weights were 0.591 ±0.064, 0.49 ±0.057, 0.47 ±0.065, and 0.443 ±0.073g. There is no significant difference in survival rate, all higher than 75%. In addition, the water saving is 80%. It is a stable method for mediate nursery of white shrimp. The compensatory growth was not significant in the comparison test of grow out portion between the two stage cultivation and one stage traditional culture. The average weight(20.01±0.02g) and yeild(4.46±0.13kg/m3 ) with one stage traditional cultivation are better than average weight(18.35±0.22g) and yeild(4.34±0.11kg/m3 ) with two stage cultivation, but it is minor difference. Considering the efficacy of epidemic prevention, the mediate nursery for white shrimp is advantageous.