Recirculation culture more than 300 grams grouper, soy protein replaces fishmeal ratio 0, 20, 40, 60, 80, 100%, adding 1% taurine and adjusting with 2-hydroxy-4-methylthiobutanoic acid in the feed, the content methionine level was 1%, the crude protein was 45% and the crude fat 6% of the test feed, during 10-weeks rearing test, the optimal growth replacement was 56.1% by broken-line regression analysis of percent weight gain.