This study investigated the factors that have caused mass mortality of the oyster industry in Taiwan, including various abiotic and biotic factors. We found even if the feeding ability changed after the treatment, oysters can still survive in the environment with low temperature which’s lower than the average in the west coast of Taiwan. In the low salinity experiment, except oysters with 0‰ treatment occurred mass death and all died within 12 days, oysters with 5, 10, 15, and 20‰ treatment didn’t occur a large number of deaths, and the survival rate was 100%, 90%, 97%, and 97%. The oyster drill, the most destructive predator in the oyster culture were collected monthly. In June, a large amount of hyperplasia occurred, the density of oyster drill is extreme higher than the past months. We suggest that the manufacter should increase removal of the Thais species during the period to avoid affecting the harvest.