For provide the seed industrial development. The purpose of the study is to understand the processes of artificial propagation ofMercenaria mercenaria. Propagation process is to select mature broodstock and to cool dry for four hours, then put into 3.5 tons of glass fiber water tank for spawning , After the eggs absorbing water are round about 60-70 μm in size, After 15 minutes ,the fertilized eggs will be the first polar body (1st Polar body), 30 minutes after the split into 2-cell stage, 1 hour split into a 4-cell stage, after 2 hours split for the 8-cell stage, after 4 hours 10 minutes split for morula stage, and began to turn, after 12 hours develop into trochophore and the size is about 90 μm, after 16 hours develop into the D-stage juvenile and the size is about 110μm, these stage began planktonic life. After feeding 168 hours, the size of larva is about 190μm ,the foot began appeared and enter the metamorphosis stage. 30 days of incubation seedlings can grow to 0.6 ~ 1.2mm and shell show a translucent. After 60 days incubation, the size of spats was about of 2 ~ 4mm .