Synbiotic is a combination of probiotics and prebiotics, the benefits of increasing growth performance and disease resistance of aquatic animal are generally higher than the effectiveness of the two alone. Currently, probiotics on the market rarely produce prebiotics. Previous studies have indicated that Leuconostoc mesenteroides B4 and its prebiotic product, dextran, help to increase the growth of spotted grouper and tilapia. Bacillus pumilus D5 can reduce the number of Vibrio in the water and hepatopancreas of white shrimp, improve the immune response of white shrimp and the function of resisting Vibrio parahaemolyticus infection. In addition, B. subtilis N4 can help reduce organic compound and nitrite in water. In this study, the probiotics L. mesenteroides B4 + dextran + B. pumilus D5 + B. subtilis N4 were added to the feed of the white shrimp. To investigate the effects of L. mesenteroides B4 + dextran + B. pumilus D5 + B. subtilis N4 on the growth and disease resistance of white shrimp, and water quality. The goal is to develop probiotic and its dextran products that improve the growth and health of the white shrimp, shorten the breeding time of the shrimp, and reduce the cost and risk of breeding. Then construction a safe and efficient green aquaculture system to promote the upgrading of the aquaculture industry.