In ontogeny of fish, metamorphosis is a phase between larval and juvenile periods.Elevated mortality rates during or shortly after metamorphosis have reported for manyfishes, and grouper are ones of them. The high mortality could be caused bydeteriorating water quality, viral infection, and cannibalism. Additionally, sincemetamorphosis includes major changes in morphology, either internal or external,unsuccessful transitions of those from larval to juvenile periods could makemetamorphosis quite hazardous time for the developing fish. However, so far, rarestudies concerning metamorphosis of grouper have been reported. Herein, we willinvestigate development of digestive tract and thyroid of grouper with histologicalmethods. Successful transitions of the two organ systems during metamorphosis are vitalfor grouper fry. The basic study should be helpful for larviculture of grouper.