The purpose of this study is to apply the cost-effective and durable materials to build biosecured facilities to create SPF environment for culturing SPF white shrimp, Penaeus monodon in infested area. Then it will served as demonstrate farm open to the shrimp farmers to facilitate the transfer of the technology. Tungkang Biotechnology Research Center: SPF white shrimp were cultured in a biosecured HDPE pond of 550 m2 for 180 days at culture density of 50 shrimp/m2. At harvest, shrimp grew from 0.03g to 30.2 g with survival rate of 67.7%, yield of 1.02 kg/m2, growth rate of 1.16 g/week and FCR of 2.34, respectively.