The disease resistance of sea-cage farmed cobia juvenile is low after transfer into the sea cage, resulting in low survival rate. The possible cause is due to the inbreeding depression. The purpose of this study is aimed to compare the breeding performance between the wild-juvenile reared broodstock and in-bred broodstock. The sex ratios of wild broodstock is 1.62 (♀/♂,n=76). Despite the gonad can be mature in the captivity but no any natural spawning was found in four-year-old wild-juvenile reared broodstock. Natural spawning can not be induced in captivity. Natural spawning is also not occurred in their 3-year old F1 progeny. Their natural spawning ability is under observed. On the other hand, the in-bred line cobia broodstock is fecund with high spawning frequency in first two year since full maturity. As a result, the broodstock must be culled after two-year since spawning.