The objectives of this study were to investigate the effects of the different content of yeast, photosynthetic bacteria and spirulina in dietary on the growth in hard clam. The test dietary divided into ten groups were the control group, added 1,3,5% yeast groups, added 1,3 , 5% photosynthetic bacteria groups and added 1,3,5% spirulina groups. The initial averages 19.37 mm and 1.84 g of hard clams were used for the test. Every three days threw 2% dietary of total body weight in hard clam for 80 days. The test resulted in shell length, 5% spirulina and 1% photosynthetic bacteria groups were best and significantly higher than other groups, followed by 3% yeast and 5% of photosynthetic bacteria groups, the worst were 3% photosynthetic bacteria and the control groups. In weight increases, the 5% spirulina group was significantly higher than other groups, followed by 1% of photosynthetic bacteria and 3% yeast groups, the control group was the worst and significantly lower than other groups. In the condition factor, 3% yeast, 5% yeast and 5% spirulina groups were significantly higher than other groups, followed by 1,3,5% Photosynthetic Bacteria Group, the worst were 1% spirulina,3% spirulina, 1% yeast and control groups. The survival rates were from 92.38% to 100%, and no significant difference among groups.