Cobia, Rachycentron canadium, is one of the most potential sea-cage farmed fish species in Taiwan. Recently, we find that the disease resistance of cobia fingerlings is low, resulting in low survival rate. The possible reason is probably due to the inbreeding depression that cause cobia early-maturing and growing up slowly. We want to solve this problem by using selected breeding method to improve the growth performance and disease resistance of cobia fingerlings. The purpose of this study is aimed to compare the growth performance, feed conversion ratio and disease resistance between the progeny of wild-catched cross artificial reared broodstock (Hybrid) and in-bred artificial reared broodstock(Inbred). Results show that the performance of Hybrid is better than Inbred including egg fertilization rate, egg average diameter, post-hatching larvae deformity, larvae starvation, larvae hypoxia tolerance, feed conversion ratio (FCR) and the resistance to Photobacterium damselae subsp. Piscicida. In conclusion, the study showed that hybrid cobia progeny is better than inbred and improved the quality of the seed.