The study was to investigate the effects of dietary antioxidants on growth performance and oxidative stress status of grouper. Six trial diets were formulated to be iso-nitrogenous (500 g/kg), iso-lipidic (70 g/kg). The trial diets was supplement with various the combination of vitamin C (100 or 300 mg/kg) and E(150, 300 or 600 mg/kg). Feed were hand fed to homogenous groups of 12 Epinephelus coioides juvenile (mean weight 4.2 g) per tank in triplicate for 8 weeks, in a recirculation system. Fish fed the diet supplement 300 mg of vitamin C/kg diet performed significantly better than fish fed the control diet. There was a tendency to higher SOD activities in plasma than in control grouper. There was also a tendency tolower TBARS values in muscle than in control grouper. Results of this study suggested that combination of higher vitamin C and E supplementation could help growth performances and decrease muscle TBARS values.