The cage culture popular species of cobia. Development special artificial diets are veryimportant for decrease cost and improvement the meet quality of cobia. Optimal lipidrequirement and quality increased growth and sparing the protein requirement of cobia.The dietary supplyment nucleotides for vertebrates increased lipids utilization. Thisstudy will conducted to determine the nutrition valuable of nucleotides for cobia. Theexperiment diets will prepared for supplement 0, 0.05, 0.1, 0.2,0.4 and 0.6 %nucleotides mixture with AMP、GMP、CMP、UMP and IMP in equivalent amountto evaluating the percentige weight gain, Food conversion ratio, survival rate andcondition facter for cobia. After feeding test analsing the lipid and fatty acid of muscle,liver and serum to estimate the nucleotides on lipid utilization of cobia.