農業部-水產試驗所全球資訊網農業部-水產試驗所全球資訊網

本文旨在探討靜脈注射、連續口投與藥浴等不同給藥方式下，點帶石斑Epinephelus coioides 對 Flumequine 的吸收、分布與排除之狀況，目的在建立藥物動力學參數與其生物可用率資料。實驗結果顯示，以 20 mg/kg魚體重劑量之藥物對點帶石斑靜脈注射投藥，其血液之曲線下面積 (AUC)為 249 gh/ml，血中最高藥物濃度 (Cmax) 達 42.3 g/ml，分布半生期 (t1/2 ) 為 0.3 h，排除半生期 (t1/2 ) 為 10.5 h。另以 20 mg/kg 魚體重/天之劑量對點帶石斑連續口投給藥四天，結果魚體對藥物的吸收，在第二天時達穩定狀態，其平均血中濃度 (Css ave) 為 4.6 g/ml。以劑量 20 ppm 對點帶石斑連續藥浴三天，結果魚體內藥物濃度，在連續藥浴三天後達最高，其 Tmax 為三天，Cmax 為 1.2 g/ml。至於將藥物經口投與藥浴方式投藥之生物可用率，分別為 44 和 9%。

The absorption, distribution and elimination of flumequine in orange-spottedgrouper Epinephelus coioides were studied after various routes of administrationat 23oC. The area under the serum concentration-time curve (AUC) was 249 gh/ml after the fish was given a single intravenous injection at a dose of 20mg/kg b.w. Distribution and elimination half-life (t1/2, t1/2) of flumequinewas 0.3 and 10.5 h, respectively. The drug was absorbed and eliminated rapidly.Flumequine reached a peak concentration (Cmax) of 42.3 g/ml in serum. Asteady-state level of flumequine was achieved on the 2nd day in serum, muscle,liver and kidney of fish after four consecutive days of oral administration atdose of 20 mg/kg b.w./day, and an average concentration (Css) of flumequine inserum was 4.6 g/ml. The peak of flumequine concentration in serum was 1.2 g/ml on the 3rd day after consecutive bathing administration at dose of 20 ppmfor three days. The bioavailability of oral and bathing administration was 44and 9%, respectively.