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為瞭解傳統中藥材海馬之功效性，同時達到抑止濫捕野生海馬之現況，本研究完成海馬及其複方中藥材之功效評估，以及養殖（庫達）海馬取代野生（棘）海馬之可行性評估。庫達海馬與棘海馬之一般成份以粗蛋白含量最高，其次為粗灰分，而兩種海馬的重金屬含量均在法規安全規範下。海馬之熱水及酒精萃取物具良好之抗氧化能力，但螯合亞鐵離子能力不佳，均在10％以下。此外其熱水及酒精萃取物能促進HB4C5免疫細胞增生及其IgM抗體分泌，亦能活化J774.1吞噬細胞活性達143％。酒精萃取物經體外消化後仍能活化SHSY5Y神經母細胞達130％，在顯微鏡下觀察其細胞型態完整且神經突觸長度有延伸。但在等量蛋白質濃度下，病死海馬之熱水萃取物其活化HB4C5免疫細胞及促進抗體分泌之能力均較正常海馬組低。而在動物實驗部分，餵食庫達及棘海馬熱水萃物之小鼠較控制組相比，均能延長其游泳時間、降低小鼠運動後血清中的肌酸激酶及尿素氮之濃度，顯示具有抗疲勞之效果，故推測庫達海馬具有取代棘海馬之可行性；然而在調節免疫評估上則餵食海馬組均與控制組無差異。

研究報告摘要(英) In order to know the efficacy of traditional Chinese medicine, seahorse, and inhibit the spreading catch of wild seahorse, therefore our study focused on seahorse and it’s compound prescription efficacy, and estimated the substitute possibility of cultivated Hippocampus kuda seahorse. Crude protein is the major portion of H. kuda and H. erinace, and the ash as follow, however the heavy metal content of these two seahorses are safe for edible. The hot water and alcohol extract of seahorse have good antioxidative abilities, but the chelating Fe+2 activities are low to 10%. Furthermore, both two kind of extracts can activate the proliferation of HB4C5 cell and J774.1 cell, and also can stimulate HB4C5 cell to secret IgM antibody. After in vitro digestion of alcohol extract, which still can activate the proliferation of SHSY5Y cell to 130%, and under the microscope we can observe that the axons of cells are extended. But under the same protein content of hot water extract, the sick H. kuda can not activate the proliferation of HB4C5 cell as normal H. kuda extract. In animal test, the hot water extract of H. kuda and H. erinace all can elongate the swimming time of mice, and reduce the concentration of creatitine and urinary urea nitrogen in serum, so it is suggested that the hot water extract of H. kuda has the ability of anti fatigue, but there is no effect on immunomodulatory. So we suggest that cultured H. kuda may have the possibility to substitute of H. erinace.