Periodontitis is a related bone chronic inflammatory disease. Alveolar bone atrophy occurs predominantly in seniors. In this study, we established an experimental platform on inducing differentiation of RAW264.7 cell into osteoclasts, analyzed the effects of SQ-liposome on inhibiting the osteoclastogenesis, and developed a molecular gastronomy with suppressed function of the bone resorption. Our results show that co-treated with 20ng/m of RANKL (receptor activator of nuclear factor kappa B) and 33.3 ng/mL of M-CSF (macrophage colony-stimulating factor) successfully induced the osteoclast differentiation from RAW264.7 cell. Incubation with 0.12~1 mg/mL of SQ-liposomes for 72h, both of RAW264.7 and differentiated osteoclast groups were >80% (P <0.05) on cell viabilities, and the same dosage also shows that inhibited the TRAP activities, and suppressed the multi-nuclear osteoclasts (MNCs) formation (P <0.05) within 0.11~1mg/mL. The artificial fake salmon roe containing with SQ-liposome were manufactured by sodium alginate solution. The measure of Hunter Lab and texture profiles were carried out. The results showed that the L*, a* and b* of the artificial roe with means were 76.3±0.01, 16.8±0.02 and 54.7±0.04, respectively. The toughness (g), chewiness (g.sec) and stickiness (g.sec) of the artificial roe from 2% sodium alginate prepared were 90.8 ± 8.8 and 88.3 ± 6.6 and -0.1 ± 0.1, respectively. In this study, we developed a delicious artificial roe with an inhibited bone resorption function (from SQ-liposome). We respected that product could increase the appetite of the seniors also improve the health of dental.