Macrophage engulfed apoptotic cell in resolved inflammation is an important physiological phenomenon. Recently, there has been much attention focused on using mimicry of apoptotic cell trigged an active “suppressive” process on inflammation. This present study evaluated the resolving inflammatory effects of administrated squid skin liposome (SQliposome) on in-vitro LPS induced macrophage pro-inflammatory gene expression and in-vivo carrageenan induced paw edema in mouse. As our invitro results, 0.25 to 2.5mg/ml of SQ-liposome showed that suppressed LPS induced pro-inflammatory related mRNA expression on Raw264.7 cell, including IL-1β, IL-6, TNF-α and iNOS (P<0.05) but not CoX-2. In invivo results, administration of 60mg/kg SQ-liposome was observed on accelerated reduction of paw inflammatory swelling after carrageenan induced paw edema for 24~72h. Histpathological and immunostaining results also showed that SQ-liposome not only decrease monocyte infiltration but also suppressed iNOS expression on paw tissue. Our results suggested that using SQ-liposome as mimicking apoptotic body may be useful therapeutic strategies for inflammatory disorders.