Repeated infection, inflammation, or exposure to damaging environments during wound healing may lead to overexpression of TGF-β receptors, which results in hypertrophic scars and even keloids. In the 110-111 reports, they pointed out that the functional components of Botryocladia leptopoda showed wound healing ability, regulated the excessive expression of metalloproteinases, and inhibited for the accumulation of melanin, represented that these functional compounds improved superficial scars and collapse formation of scars. In this study does further analyze the ability of the functional components of B. leptopoda to inhibit the formation of hypertrophic scar tissue and to develop a healthcare product for application on skin care, which is expected to increase the algae utilization and its economic value.