The development of the high-intensive culture system in the aquatic
animals has been accompanied by the occurrence of disease outbreaks.
Emergence of disease in aquaculture industries implies serious financial
lose. The use of antibiotics and chemicals for disease control produces
detrimental side effects such as toxicity, resistance, residual impacts
on public health and environmental hazard. The natural extracts from
crude drugs used in human therapy are very popular all over the world. An
attempt to develop a series of extracts from crude drug used on the
aquatic animals for the disease control and prevention based on the
therapeutic efficiency and low hazard from the natural sources to
environment and organisms. The potent crude drug is screened against
pathogens of the aquatic animals by agar well diffusion method, and then
prepared becoming the diets containing natural extracts for the feeding
experiment in vivo. During and after feeding, the aquatic animals will be
sampled at different intervals for the analysis of activity or for the
challenge experiment using athogens of aquatic animals. The therapeutic
effect of the crude drug will be established for development the treatments of crude drugs for diseases control and prevention of aquatic
animals.