This study used 1.8 tons FRP tank to culture tilapia under zero water exchange condition. In the salinity of 0,10, 20 psu, growth reduced as salinity increased, while survival only decreased in 20 psu. In the density of 10. 20. 30/m2, with bag or not, survival rates were more than 98.3% in all groups, but growth decreased as density increased. The difference in growth was small between density of 10 and 20, therefore, the yields were 80-90% higher in 20/m2 compare to that of 10/m2 with water saving of 44-48%. Water exchange, bag and mat can remove solid and nitrate in the water column and promote growth of tilapia. Bag and mat can further stabilize pH. While bag had best ability in removing solid and nitrate, mat had best growth of 3.35±0.23 g and yield of 12.7±0.8 kg/m3. In mat group, to produce one kg of tilapia, least water of 79±5 liter was used, which saved 72% compared to exchange group. By comparison with traditional tilapia culture, under zero water exchange condition, survival rate of tilapia can reach to 100%, yield can increase more than 4 times and save water for more than 98% without decrease in growth and FCR.