Cobia, Rachycentron canadium, is one of the most potential sea-cage farmed fish species in Taiwan. Recently, we find that the disease resistance of cobia fingerlings is low, resulting in low survival rate, early-maturing and growing up slowly. These are probably due to the inbreeding depression of cobia and we will solve this problem by proceeding cobia selected breeding. We progress propagation of cobia outbred line and culture fingerlings in sea-cage to verify the feasibility of selected breeding in cobia. Results show that the outbred breeder reproduce 16 times in this year and the growth rate of sea-cage fingerlings is no difference between outbred and inbreed lines. We culture three cobia bath in respect of grow fast line(16), P. damselae resistant outbred line(30) and inbred line(30).